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114 Additionally, ER can engage directly with other proteins, including those involved in growth signaling pathways, which, in turn, amplifies the transcription of genes that are pivotal for cellular expansion and resistance to apoptosis

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192 Paradoxically, ROS can modulate ferroptosis by regulating SLC7A11 expression through the Nrf2-mediated pathway

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However, in the case of immune dysfunction and other pathological conditions, these pathobionts can greatly proliferate in a short time period, or translocate from the intestine to other parts of the body to be pathogenic [28]