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While the causative efficacy of individual cytokines on the development of certain immunopathogenic parameters in this condition is yet to be fully understood

19 Molecular characterization of isolate The isolate showing significant activity underwent molecular characterization using universal primers

Importantly, 5FU-based combination treatment also shows an increase in mitochondrial mass (FOLFOX (5FU + 1 M oxaliplatin) or FOLFIRI (5FU + 5 nM SN38, active metabolite of irinotecan)) that we attribute to 5FU-imposed stress, given that single-agent oxaliplatin or SN38 do not promote the same degree of mitochondrial adaptation (Extended Data Fig

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Prepare the Syringe Remove the syringe cap