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Description

Houtkooper, R

Bottom: volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from ER-tag HEK293T cells treated with glucose deprivation compared to glucose repletion

Madsbad 2016)

Increased levels of total lipids, cholesterol, and TG in this study could indicate high lipid peroxidation, which is associated with glycolipid metabolism disorders, loss of cell membrane integrity, and increased energy demand, resulting in cell damage, lipid accumulation, and apoptosis (Saad et al