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This work was supported by Grant-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan (23700900 to EY

MTHFR also helps generate 5-methyltetrahydrofolate (5-MTHF) from 5,10-methylenetetrahydrofolate (5,10-MTHF), which is the active form of folate that is needed for DNA synthesis and methylation reactions

One way of providing evidence that these metabolic abnormalities may be integral to important pathophysiological processes is to determine if correcting them will improve ASD symptoms