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The therapeutic constellation of natural dietary compounds reveals honey polyphenols as extraordinary microbiome architectsthese bioactive molecules fundamentally reconstitute intestinal microbial communities, particularly enriching Bifidobacteriales and S24_7 bacterial populations, thereby amplifying SCFA production cascades

Its prevalence has grown substantially worldwide, with projections from the World Health Organization estimating 2.3 billion overweight adults and 700 million obese individuals by 2025 (PAHO, 2023)

However, infection by a virulent strain of P

coli to decrease lifespan and healthspan of the host and define the critical role of detoxification genes in maintaining health during a chronic high-sugar diet