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Importantly, the M1/M2 classification is considered an oversimplification of macrophage functional spectrum

Nat Rev Clin Oncol 13(8):516-524, 2016

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Proteomics analysis revealed that the carbonylation of a set of six proteins from plasma and liver was downregulated with the supplementation of a marine-inspired EPA: DHA (1:1) blend compared to placebo [50]