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Several studies demonstrated the beneficial effects of the therapeutic targeting of IBP signaling at the level of farnesyl diphosphate synthase (FDPS), which can be inhibited by bisphosphonates (BP) or nitrogen bisphosphonates (NPBs), the drugs most commonly used in the management of MM bone disease, acting by reducing bone resorption and increasing bone density through inhibition of osteoclast activity [103]

Losing weight reduces uric acid levels in the blood and for many people, the more weight they lose, the more their uric acid levels decrease

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