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Building on our previous published work, we employed an immunopeptidomic approach to identify surface-presented mycobacterial antigens following infection of THP-macrophages with BCG or MTB ( in silico -based approach to analyze the repertoire of MHC-bound peptides present in each identified antigen, allowing us to optimize candidate antigen selection based on epitope richness

Three patients had renal insufficiency as the likely cause for their anemia, with serum Cr values between 3.0 mg/dL and 5.4 mg/dL

Pregnant women were not excluded

This is an important nuance: GLP-1 therapy, including orforglipron, is primarily a metabolic intervention