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But what may actually be happening is a condition called Estrogen Dominance, where there is an increase in the overall estrogen burden in the body

However these ligands can be expensive and unstable to the sterilization and cleanin conditions used in manufacturing process of biologics because of their biological origin, chemical nature and production methods

Targeting CAF-derived IL-6 in combination with immune checkpoint blockade (e.g., anti-PD-L1 therapy) has shown synergistic effects in reducing tumor progression and prolonging survival in preclinical models, underlining the contribution of IL-6-driven MDSC recruitment to immune suppression in PDAC