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and the effects of sex and age on vaccine efficacy (reviewed elsewhere [5, 29, 30])

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C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

this occurs because there is not enough vitamin B12 in the diet, or poor absorption Pernicious anemiaa type of megaloblastic anemia caused by a lack of intrinsic factor, so that vitamin B12 is not absorbed Fatigue, weakness Nerve damage with numbness, tingling in the hands and legs Memory loss, confusion Dementia Depression Seizures Up to 15% of the general population has a B12 deficiency