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Pathophysiology and Epidemiology PAD is caused by atherosclerotic narrowing or occlusion of arteries, most commonly in the legs

(2020) 367(6478):eaau6977

Kaushik A, Fomicheva J, Boonstra N, Faber E, Gupta S, Kest H

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In each case nucleic acids encoding the respective polypeptide, and which exhibit sequence diversity (e.g., that observed in cDNA libraries from activated T cells from human and other primates), are subjected to reassembly (&/or one or more additional directed evolution methods described herein) and screened to identify those recombinant nucleic acids that encode a polypeptide having improved activity