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Discussion BaP is considered one of the most potent hepatotoxic members among PAHs which is ubiquitously emitted into the environment via the partial combustion of organic substances such as engine exhaust and industrial activities (Karimpour Malekshah et al

Merry TL, Chan A, Woodhead JST, et al

Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology