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Consequently, multicenter, longitudinal studies involving larger and more heterogeneous populations are essential to rigorously validate these methylation markers, evaluate their reproducibility, and establish standardized thresholds for clinical decision-making

Lactate is produced through ULK1-mediated phosphorylation of LDHA and facilitates the lactylation of PIK3C3/VPS34 at lysine residues 356 and 781 via the acetyltransferase KAT5/TIP60

Eleftheriou D, Benetou V, Trichopoulou A, La Vecchia C, Bamia C

doi: 10.1038/ncb1589

Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondrial function and mitophagy balance in rats