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Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-B/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway

The largest randomized placebo-controlled double-blind trial evaluating use of vitamin E, which involved 207 patients treated with taxanes or platinum agents, failed to show significant differences in incidence of neuropathy, time to neuropathy onset, or need for chemotherapy dose reduction.[27] Without any strong evidence available to support its use, vitamin E is not recommended for CIPN prevention.[17] Vitamins, minerals, and other natural approaches that appear promising but for which more evidence is required Omega-3 fatty acids

PLoS ONE 7 , e4367 (2012)

XPD is a crucial subunit of the transcription initiation factor TFIIH, which is involved in NER and transcription ( The mutations of XPD gene are related to three genetic diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD) (White, 2009