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[PubMed: 23633205] 337

CD36-mediated metabolic rewiring of breast cancer cells promotes resistance to HER2-targeted therapies

However, variant interpretation is complicated by factors such as membrane targeting: for instance, a serine mutation at one of the other Na + -binding residues, N210, causes a reduction in uptake, but also shows mixed localisation, 11 which may itself contribute to disease

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