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Das D, Cho H, Kim N, Pham TTH, Kim IG, Chung EJ, et al

In this manner, out of phase oscillations of PER/TIM protein and mRNA are generated, rather than a constitutively expressed homeostasis that a negative feedback loop would typically produce ( The Drosophila circadian clock in the eye is thought to be sustained by the same oscillations of PER protein that drive the circadian clock of the brain

It is also advised to avoid alcohol for better treatment, as consumption of alcohol decreases the absorption of vitamin B from the gastrointestinal tract

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7 , e1002453 (2011)