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Surgical procedures for 1-week oIGF-1 infusion To test the chronic effects of oIGF-1 on fetal growth and anabolic signaling pathways, pregnant Columbia-Rambouillet mixed-breed sheep (n = 6) carrying twin fetuses underwent maternal laparotomy and hysterotomy under general anesthesia for fetal catheter placement as previously described ( 3 biopsy was obtained from the BF muscle of each fetus and frozen at 70 C in order to measure baseline isotopic enrichment of phenylalanine prior to tracer infusion

Key research domains include: Inflammation Suppression Models investigation of cytokine downregulation (IL-1, TNF-) in epithelial and immune cells

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Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation

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