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1 Introduction The RBD (receptor-binding domain) is a critical subdomain of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike glycoprotein, which is responsible for COVID-19 (coronavirus disease 19) ( The receptor-binding motif (amino acids 438-506) of RBD elicits neutralizing antibodies, making it a potent COVID-19 vaccine immunogen (Krammer, 2020

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