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8 Limitations and evidence gaps Key gaps include limited long-term randomized clinical trials, variability in intervention timing and dosing, and insufficient stratification by age, sex, chronotype, and comorbidities

Polymeric nanoparticles : controlled release systems (e.g., PLGA-based)

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21 Over these timescales, animals display low-activity dwelling behaviors in high-quality food, and higher-activity roaming behaviors when food is limited