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Similarly, males with hepatocellular carcinoma present both a higher incidence and more aggressive tumor phenotypes than females do, and female patients with higher GPER activation generally present with smaller tumors and prolonged survival [77]

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which can also account for microbial changes A report highlighted that pandemic-period study populations were an un-homogenic group of unvaccinated, vaccinated, infected previously, and never-infected persons and that it was no longer easy to determine which microbiome changes were attributable to COVID-19 and not to pre-existing immunity or other factors [61]