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The evolution of aerobic respiration by mitochondria increased cellular production of superoxide, resulting in an increased reliance upon SOD1

According to Shuja et al 11 study, risk factors for melasma other than GSH, there was also a decrease in levels of other antioxidants such as superoxide dismutase (SOD), catalase, vitamin E, and vitamin C which were statistically significant in melasma subjects compared to controls

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These experiments were conducted using a specialized photocatalytic device equipped with a stirring mechanism, maintained at a constant temperature, and illuminated by two 35 W xenon lamps