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Alternatively, the level of ROS-generated in these cells may not be overcome by only overexpressing a single antioxidant enzyme, or, perhaps, the basal level of hydrogen peroxide is low such that its removal may promote apoptosis

IV times vary

These experiments suggest that Epithalon may be useful in exploring mechanisms of photoreceptor preservation, retinal signaling, and neuroprotective strategies in the eye

One explanation for this may be their functional redundancy shared with certain PRXs

Beyond the toxic gain-of-function effects of mHTT, HD pathogenesis involves a range of interconnected mechanisms, including mitochondrial dysfunction, transcriptional dysregulation, impaired autophagy, proteostasis failure, excitotoxicity, oxidative stress, and chronic neuroinflammation [3843]