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found that ROS depletion not only reduced ox-mtDNA production and the binding to NLRP3, but also prevented NLRP3 deubiquitinating, thereby suppressing NLRP3 inflammasome activation

Recent research on cardiovascular disease treatment has focused on various natural or synthetic active compounds that protect mitochondrial function and maintain energy production

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, et al

Comparison of the short-term results of single-dose intra-articular peptide with hyaluronic acid and platelet-rich plasma injections in knee osteoarthritis: a randomized study. Clinical rheumatology 39.10 (2020): 3057-3064

This work presents an example of interplay among BBB/neurovasculature, the microbiome and neuroinflammation