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These changes contribute to neuroinflammation, bloodbrain barrier (BBB) dysfunction, microglial activation, and neurotransmitter imbalances

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Canadian journal of biochemistry

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Natural flavones like quercetin and apigenin act as TrkB agonists, directly binding to the receptors extracellular domain to activate the downstream CREB pathway, thereby reducing apoptosis, oxidative stress, and protein aggregation in cellular models of neurodegeneration (Chiu et al., 2023)