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A cautious approach is to start low, change one thing at a time, and stop if symptoms appear

Choose whichever supports your routine best

Ultimately, activation of matrix metalloproteinases degrades collagen matrices and promotes smooth muscle cell apoptosis, leading to plaque destabilization [322]

For example, increased arginase activity enhances polyamine synthesis while limiting nitric oxide production, shifting the balance between proliferative and immunomodulatory outputs

Consider a series of treatments rather than a single session for persistent symptoms, as cumulative benefits often provide more sustainable improvements