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Acknowledgements Our work was supported by National Key R&D Program of China (2020YFA0803200, 2023YFC2505903), the National Natural Science Foundation of China (31930026, 32200567, 92168116, 82373251, 82222052, 82372613, 82150112, 82361168638, 32070710, 32270747, 82072740, 32170706), the Science and Technology Commission of Shanghai Municipality (23YF1432900, 22ZR1448100, 22QA1407200, 22QA1407300, 23ZR1480400, 23ZR1448900), the Guiding Funds of Central Government for Supporting the Development of the Local Science and Technology of Shanxi Province (YDZJSX2021B016, YDZJSX2021B015), China Postdoctoral Science Foundation (2019M651610) and Shanghai Super Postdoctoral Incentive Program

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GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring tripeptide-copper complex first isolated from human plasma by Pickart and Thaler in 1973