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According to Harvard Health, B12 deficiency can be sneaky and harmful often developing silently over years before symptoms become apparent

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As we know, the pathological mechanisms of OIC includes the binding of exogenous opioids to peripheral - and -opioid receptors in the submucosal and myenteric plexuses of the ENS (Bagnol et al., 1997

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For researchers on lower doses (2.5 to 5mg), the 10mg vial hits the sweet spot