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Also, the cumulative need for colectomy after 10 years was 9.8%, nearly 50% of the patients were relapse-free in the last five years of the study, and only 20% of the patients with proctitis or left-sided disease progressed to pancolitis

MalaguarneraMPistoneGAstutoMVecchioIRaffaeleRLo GiudiceEet al

Arch Pharmacal Res 26:906911 Jia S, Hu C (2010) Pharmacological effects of rutaecarpine as a cardiovascular protective agent

Protein Binding and Lipophilicity: Protein Binding and Lipophilicity: Of the many factors, perhaps the two most important and useful are the degree of protein binding, and lipid solubility