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Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

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doi: 10.1046/j.1469-8137.1999.00477.x 27 KassellB.BrandE

A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity

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