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To exclude the effects of these metabolic intermediates on pyroptosis, we then pretreated hepatocytes with L-methionine (L-Met) or tetrahydrofolic acid (THF) and found neither can block GSDME-mediated pyroptosis (Supplementary Fig

K., Hambleton, I

Laboratory investigations show that BPC-157 administration significantly enhances ERK1/2 phosphorylation in a dose-dependent manner, leading to increased endothelial cell proliferation, migration, and vascular tube formationthe central processes underlying functional angiogenesis in tissue regeneration contexts

Both authors contributed to the article and approved the submitted version

Phase IV clinical trials of the mRNA-1273 vaccine are currently underway (NCT04760132, NCT05060991, NCT04952402, NCT05030974, NCT05047718, NCT05075538, and NCT05075538) ( The mRNA-1273 vaccine is still effective for the Alpha variant, but its neutralization effect on the Beta variant is reduced