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This is mostly through the formation of new blood vessels as well as enhanced nitric oxide signaling, a key vascular molecule that helps dilate blood vessels

10.1016/j.apsb.2021.12.023 91 XieX.LiH.WangY.WanZ.LuoS.ZhaoZ.et al (2019)

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In hepatic MTs, out of 1,033 sequenced miRNAs, 186 (=18%) were DE with approximately half of the miRNAs being upregulated (47.3%)

Overall, dietary histidine is critical not only for growth and metabolic functions but also as a protective agent against oxidative stress and hypoxic injuries in fish