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In one completed study, the rate of lymphoproliferative disease in RA patients receiving higher than recommended doses of azathioprine (5 mg/kg per day) was 1.8 cases per 1000 patient-years of follow-up, compared with 0.8 cases per 1000 patient-years of follow-up in those not receiving azathioprine

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Rhamnetin also plays a role in overcoming MDR by downregulating MDR proteins like P-glycoprotein, thereby enhancing the effectiveness of chemotherapy agents [64, 65]

Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3

doi: 10.1016/j.cellsig.2020.109838 49 FuchoR.CasalsN.SerraD.HerreroL