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And more recently, prescription NAD+ therapies delivered via nasal spray, like Midi's NAD+ Nasal Spray, have emerged as an alternative to oral supplements and IV clinics

This process renders harmful compounds water-soluble so they can be safely excreted by the body

This altered the conformation state of pyruvate kinase M2 (PKM2) from tetrameric to dimeric and thereby favored its nuclear translocation, where PKM2 phosphorylated the transcription factor signal transducer and activator of transcription 3 (STAT3) to increase pro-inflammatory IL-6 and IL-1 production (Shirai et al., 2016)

They reported that treatment with lotus seed PCs led to a reduction in the amount of ROS generated by UV exposure, an increase in the intracellular SOD level, and decreased MDA production, thereby mitigating oxidative stress-related damage to the skin