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10.1038/ncomms1382 25 Fritz-WolfK.UrigS.BeckerK

Research documents CNS-mediated mechanisms distinct from peripheral vascular pathways

At the cellular level, capsaicin downregulates lipogenic genes including SREBP-1c, FAS, and ACC, while upregulating lipid oxidationrelated genes such as PPAR and PPAR in hepatocytes (12, 45)