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Mass spectrometry (LC-MS) identity confirmation

Delivery of repRNA into cells promotes synthesis of antigen-encoding RNA that self-adjuvants by triggering innate immune responses and promoting antigen cross-priming which enhances humoral and cellular immune responses compared to conventional mRNA

Significantly, all APDs cause metabolic side effects to differing degrees, and current treatments to reduce these metabolic symptoms have only limited efficacy 4

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What Remains Unproven: Animal Studies: Laboratory research using rodent models has examined tissue processes, inflammatory responses, and biological mechanisms