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Pro-oxidant shift in glutathione redox state during aging

Vascular smooth muscle cells in atherosclerosis

Low levels of GH and IGF-1 have been associated in different cohorts with endothelial dysfunction, increase in carotid intima-media thickness (CIMT), impaired coronary blood flow, coronary artery disease, congestive heart failure, left ventricular hypertrophy, arterial hypertension, myocardial infarction, and ischemic stroke ( 3 GH deficiency in adults In adults, HGH deficiency is associated with changes in body composition, including reduced lean body tissue, skeletal and myocardial muscle, increased total and trunk fat mass (FM), osteopenia or osteoporosis, and dry, thin, wrinkled skin

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Glutamine availability up-regulates expression of the amino acid transporter protein asct2 in hepg2 cells and stimulates the asct2 promoter