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Folic acid (5mg weekly) should be given with methotrexate to reduce risk of gastrointestinal and liver toxicity[1]

van der Veer MS, de Weers M, van Kessel B, Bakker JM, Wittebol S, Parren PWHI

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Exogenous AAS inhibit endogenous testosterone production, and discontinuation of their use is often associated with a prolonged decrease in testosterone secretion ( The substances used in PCT are administered in the treatment of male hypogonadism unrelated to androgen abuse ( To restore endogenous testosterone, mainly aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs), and human chorionic gonadotropin (hCG) are used ( In the 2024 WADA Prohibited List ( Aromatase is an enzyme that converts testosterone to estradiol (the most potent estrogen form) and androstenedione to estrone ( The anti-estrogenic compounds mentioned in the WADA list can be divided into two groups: SERMs (bazedoxifene, clomiphene, cyclofenil, ospemifene, raloxifene, tamoxifen, and toremifene) and selective estrogen receptor degraders (SERDs), of which fulvestrant is a representative