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Regenerative strategies that have garnered much interest in recent years are focused on elucidating the native developmental processes of the IVD to apply early developmental signals for in vivo tissue regeneration by combining tissue engineering using biomimetic scaffolds, targeted drug delivery for endogenous cell activation and differentiation, and exogenous cell implantation (Pirvu et al., 2014

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doi: 10.1021/acs.chemrestox.7b00239