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Of note, the strongest fluorescence was observed in the GCMR group, suggesting enhanced OH production which is attributed to the further depletion of GSH by outer MnO 2 , as mentioned above (Figure 3C)

Improved MPO action, a sign of neutrophil infiltration that explains the inflammatory damaging effects in hepatic tissues, has been linked to another enzymatic pathway in the pathogenesis of INH + RFM hepatotoxicity [90]

One study, however, suggests that the prevalence of B12 deficiency in young adults may be greater than previously thought

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