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This manuscript was supported (in part) by the Intramural Research Program of the US NIH, National Center for Complementary and Integrative Health (NCCIH) and National Institute of Nursing Research (NINR)

Clinically, AS also overlaps with related disorders such as inflammatory bowel disease, psoriasis, and reactive arthritis, and patients may present with features like uveitis (eye inflammation), enthesitis (tendon/ligament insertion pain), or peripheral joint symptoms rather than textbook low-back complaints

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Oral TXA also improves the performance of adjuvant creams such as TC cream in melasma, with earlier clinical response [79]