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A key observation is the disruption of cellular homeostasis, often coinciding with disease progression

Obesity-induced protein carbonylation in murine adipose tissue regulates the DNA-binding domain of nuclear zinc finger proteins

This included a transient hyperactive state in excitatory neurons that preceded their loss, validated by acute slice electrophysiology

Clearance of eryptotic cells Multicellular organisms lose cells by different genetically controlled processes, leading to cell death, such as apoptosis and necroptosis