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Drugs such as capecitabine, methotrexate, and various tyrosine kinase inhibitors require intact renal or hepatic pathways for clearance

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In sum, ctDCS responsiveness appears intrinsically state-dependent: the neurochemical milieu, inflammatory activity, and genetic background gate both the sign and magnitude of induced plasticity, offering a coherent explanation for the between- and within-subject heterogeneity observed to date