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BCAAs, especially leucine, could be signaling molecules that are directly responsible for the pathophysiology of heart disease

Mitochondrial damage induced by conditions of oxidative stress

The passage of metabolites such as ATP, adenosine diphosphate (ADP), pyruvate, calcium ions (Ca 2+ ), and phosphate (PO 4 ) is regulated by controlling the transport proteins

The key to treatment is to deliver glutathione directly to the lungs, specifically to the epithelial lining fluid (ELF) in the lower respiratory tract

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