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This impaired FXR-TonEBP axis directly compromises renal concentrating ability [13, 30] while concurrent dysregulation of NOX2/gp91 reflects broader cellular stress response alterations

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Steinbrecht S, Kammerer S, Kpper J-H (2019) HepG2 cells with recombinant cytochrome P450 enzyme overexpression: their use and limitation as in vitro liver model

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