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In preclinical and in-vitro research models, AOD-9604 has been studied as a fragment that reproduces certain metabolic activities associated with the C-terminal portion of growth hormone, particularly effects on lipid metabolism, while being investigated separately from the growth-promoting and glucose-affecting activity linked to the full-length hormone in those same models

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Other FDA-approved drugs, including donepezil, galantamine, rivastigmine, and memantine, have demonstrated cognitive benefits but are frequently associated with gastrointestinal disturbances, dizziness, agitation, and, in some cases, severe hepatotoxicity, as observed with tacrine (Marucci et al., 2021