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In these trials, which had a median treatment duration of 12 weeks, the estimated incidence rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0.43%, compared to 0.24% among 16,029 placebo-treated patients, representing an increase of approximately one case of suicidal thinking or behavior for every 530 patients treated

These findings provided the closest available in vivo molecular signature for brain IR in depression and showed important sex differences in these pathways

Secondary NS (i.e., those symptoms secondary to psychosis, depression, extrapyramidal side effects of antipsychotic drugs or environmental deprivation) represent a further source of heterogeneity

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