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Zhang et al., 2017

Blood pharmacokinetics and biodistribution of T-AsiG-CPL in vivo Encouraged by the effective PDAC cell growth inhibition and PSC quiescence in vitro, we further investigated the pharmacokinetics and bio-distribution of T-AsiG-CPL in an orthotopic pancreatic tumor mouse model, which was established by co-inoculation of mice with T3M4-luci cells and PSC that has been demonstrated to closely resemble human pancreatic cancer by generating desmoplastic stroma 29,30

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The results indicated that the ratio of contacts between tricaprylin and CHOL increased, while those with the other two phospholipids decreased, further supporting the observed results