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The liver influences neurological function indirectly by regulating medications, steroid hormones, inflammatory compounds, ammonia, bilirubin, copper transport and many products absorbed from the gut

Much of this increase is explained by changes in diagnostic practice, including: Broadening the definition of ASD to include higher-functioning children Increased accuracy in the diagnosis of ASD (particularly for children who previously may have been diagnosed with intellectual disability) Increased awareness of the disorder Earlier identification of young children However, we cannot rule out that there is a true increase in the risk for ASD

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To investigate the effects of EMs combined with iron overload on mouse litter size, we constructed five model groups, namely, control group (CON, n = 10), EMs group (EMs, n = 10), EMs with the high iron model group (IRON, n = 10), and deferoxamine mesylate and VITE intervention EMs with the high iron model group (IRON + DFO, n = 10 and IRON + VITE, n = 10, respectively)

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