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The fundamental chemical instability of the peptide chain in a liquid solution at room temperature remains, making refrigeration essential regardless of preservatives

The body uses them as signalling molecules

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The simulated magnitude of the interaction (AUCR, 1.02) with midazolam was ~30% lower than observed (AUCR, 1.39) if only reversible CYP3A inhibition was considered, indicating that time-dependent inhibition contributes to the mechanism of the interaction

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