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Definition of diabetic peripheral neuropathy The clinical diagnosis of diabetic peripheral neuropathy (DPN) was determined using a questionnaire (Neuropathy Symptom Score) and physical examination (Neuropathy Deficit Score), which were performed by an experienced neurologist on all patients, as described previously [30]

Nonetheless, multiple sources of bias likely influenced results, including exposure misclassification (es., current shift status used as proxy for lifetime exposure), survivor bias and left truncation in cohorts, and incomplete control for reproductive or behavioral confounders 276

PMID 18443711

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Most positive trials run at least eight to twelve weeks and many go longer